The sox2 transcription factor binds rna
WebAug 15, 2024 · The Sox2 transcription factor binds RNA. Nat. Commun. 2024; 11: 1805. Crossref; PubMed; Scopus (45) Google Scholar]. These TFs with DNA- and RNA-binding function can therefore orchestrate diverse cellular metabolisms by fine-tuning the expression of target genes at both transcriptional and post-transcriptional levels. … WebHolmes, Z. E., Hamilton, D. J., Hwang, T., Parsonnet, N. V., Rinn, J. L., Wuttke, D. S., & Batey, R. T. (2024). The Sox2 transcription factor binds RNA.
The sox2 transcription factor binds rna
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WebJan 1, 2003 · The transcription factor SOX2 has also been implicated in the regulation of Fgf4 expression. We have used gene targeting to inactivate Sox2, examining the phenotypic consequences in mutant embryos and in chimeras in which the epiblast is rescued with wild-type ES cells. We find a cell-autonomous requirement for the gene in both epiblast and ... WebFatima Cavaleri, Hans Schöler, in Handbook of Stem Cells, 2004. OCT4 DOES NOT PLAY SOLO. Regulation of the FGF4 and UTF genes has provided insight into an Oct4-induced …
WebApr 14, 2024 · Europe PMC is an archive of life sciences journal literature. WebFinally, while most SPFs induce TET-dependent active DNA demethylation, SOX2 binding leads to passive demethylation, an activity enhanced by the co-binding of OCT4. This finding suggests that...
WebA typical transcription factor binds to DNA at a certain target sequence. Once it's bound, the transcription factor makes it either harder or easier for RNA polymerase to bind to the promoter of the gene. Activators Some transcription factors activate transcription. WebB lymphoma Mo-MLV insertion region 1 homolog (BMI1) and SRY-Box Transcription Factor 2 (SOX2) are two CSC-related transcription factors that have been implicated in promoting CSC self-renewal. The objective of our current investigation was to determine the role of the Shh pathway in regulating BMI1 and SOX2 expression in thyroid cancer and ...
WebSOX2 is required for multiple steps in formation of the trachea, lung, and esophagus. During these processes, SOX2 is complementarily expressed with other transcription factors, for … rbi and credit controlWebApr 12, 2024 · miRNA-140-5p has been demonstrated to play an important role in the initiation and progression of cancer, can inhibit tumor formation and metastasis of colorectal cancer and regulate the stem cells by suppressing the WNT, SOX2, and SOX9 (SRY-Box Transcription Factor 2 and 9) stem cell regulator pathways in breast cancer (D. … rbi air to water heat pumpWebAug 8, 2014 · Background The transcription factor, Sox2, is central to the behaviour of neural stem cells. It is also one of the key embryonic stem cell factors that, when overexpressed can convert somatic cells into induced pluripotent cells. Although generally studied as a transcriptional activator, recent evidence suggests that it might also repress … rbia frameworkWebNov 26, 2024 · SRY-box transcription factor 2 (SOX2) overlapping transcript (SOX2-OT) is an evolutionarily conserved long noncoding RNA. Its intronic region contains the SOX2 gene, the major regulator of the pluripotency of embryonic stem cells. The human SOX2-OT gene comprises multiple exons and has multiple tran … rbi also known asWebSox2 (SRY-box containing gene 2) lies at the center of these programs (Avilion et al., 2003; Takahashi and Yamanaka, 2006). Sox2 binds to DNA via its highly conserved HMG-box domain, often in co-operation with other transcription factors … rbi and its functionv wikipediaWebMar 1, 2024 · Transcription factor Mode of Sox2 expression regulation Mechanism of action Function(s) Expression in breast cancer Cell line used Ref. DACH1: Negative: Binds to Sox2 promoter, repressing its transcription, possibly via HDAC1 recruitment: Cell fate determination, maintenance of stemness in breast tumor stem cell: Downregulated: Basal … sims 4 cc overlay skinWebNov 1, 2024 · The Sox2 transcription factor binds RNA Nat. Commun., 11 ( 2024), p. 1805 View in Scopus Google Scholar 4. M.C. Pomeranz, et al. The Arabidopsis tandem zinc finger protein AtTZF1 traffics between the nucleus and cytoplasmic foci and binds both DNA and RNA Plant Physiol., 152 ( 2010), pp. 151 - 165 Google Scholar 5. W.C. Kim, et al. sims 4 cc oversized hoodie