Webarnines containing a -SCF3 group are very weakly basic and the -SCF3 group is brokgn off with hydrogen chloride (6); amides or amines containing the -SCF3 group would therefore not be expected to form salts with hydrogen fluoride. No reaction was observed with trimethyl- amine and bistrifluoromethyl disulfide, WebInterestingly, allylic alcohols with a Ph group and a m-Cl–Ph group or a m-OMe–Ph group proceeded via the migration of the more electron-de cient aryl group, delivered the products 3i and 3j in respective yields of 47% and 45%. Allylic alcohols with a Ph group and an o-methylphenyl group delivered the Ph group-migration product 3k in 45% yield.

Publications – Noël Research Group – UvA

WebMay 1, 2024 · The tandem reaction enables the asymmetric integration of the -SCF3 group to carbonyl compounds, establishing chiral tertiary α-carbon centers and affording α-SCF3-β-substituted carbonyl compounds in 50-92% yields with up to 20 : 1 dr and 96% ee. WebJan 25, 2024 · [9,10] Along these lines, the introduction of the SCF3 group into small molecules has attracted great attention in organofluorine methodology. [11–17] The vicinal difunctionalization of olefins to introduce two functional groups across a double bond has appeared as a vigorous transformation to rapidly increase molecular complexity in … essay on belonging to a community

Solid-state organization of semifluorinated alkanes probed by 19F …

WebThe OCF3 group is of high interest in the quest for new drugs and agrochemicals, thanks to its atypical features. This Highlight article depicts the recent and impressive advances … WebJul 2, 2014 · A range of functional groups, including ethers, thioether, esters, nitriles, amides, and ketal groups, were well tolerated in the electrophilic partner and variation of the solvent, additives and time allowed optimization of the reaction. A general and convenient copper-mediated trifluoromethylthiolation of primary and secondary alkyl halides was described. … WebD.A. Zondag, S.; Mazzarella, D. and Noël, T. Scale-Up of Photochemical Reactions: Transitioning from Lab Scale to Industrial Production. Annual Review of Chemical and Biomolecular Engineering, 2024, 14 DOI: 10.1146/annurev-chembioeng-101121-074313 finra wfh