WebFibrogenesis depends on the sustained activation of myofibroblasts, which deposit the extracellular matrix that causes progressive scarring and organ failure. Here, we showed that the transcription factor SOX9 was associated with kidney fibrosis in humans and required for experimentally induced kidney fibrosis in mice. WebMyofibroblasts are activated in response to tissue injury with the primary task to repair lost or damaged extracellular matrix. Enhanced collagen secretion and subsequent contraction - scarring - are part of the normal wound healing response and crucial to restore tissue integrity. Due to myofibrobl …
Myofibroblast proliferation and heterogeneity are supported by ...
WebJun 15, 2024 · Surprisingly, our study discovered that long-term hyperactivation of macrophages will direct their transformation into a scar-producing cell type called … WebChronic kidney disease (CKD), secondary to renal fibrogenesis, is a public health burden. The activation of interstitial myofibroblasts and excessive production of extracellular matrix (ECM) proteins are major events leading to end-stage kidney disease. Recently, interleukin-15 (IL-15) has been implicated in fibrosis protection in several organs, with little evidence … guy sitting on knees
Biomarkers for cancer-associated fibroblasts - Biomarker Research
WebJul 10, 2024 · The sequential development of mutually exclusive features and functions during myofibroblast maturation can explain seemingly perplexing findings, such as low or absent α-SMA expression in cells that express high levels of collagen during stages of … WebJul 17, 2024 · In this review, we highlight recent reports detailing the mitochondrial and metabolic mechanisms that contribute to myofibroblast differentiation, persistence, and … WebThe myofibroblast can disappear by apoptosis; while deactivation leading to a quiescent phenotype has not been clearly demonstrated, at least in vivo. ... neurons that carry signals from sensory organs toward the appropriate integration center of the brain or of the spinal cord. Several clinical observations indicate that damage to the ... guy sitting on a jar